Thiamine as an integral component of brain synaptosomal membranes.
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چکیده
منابع مشابه
Highly purified synaptosomal membranes from rat brain. Preparation and characterization.
Synaptosomal plasma membranes were isolated from whole rat brain by a method derived from several existing ones. The procedure involves the sequential centrifugation of a crude mitochondrial fraction through a discontinuous sucrose gradient and a continuous cesium chloride gradient. The material is then subjected to osmotic lysis and centrifuged through an additional discontinuous sucrose gradi...
متن کاملEvidence for protein synthesis in synaptosomal membranes.
Evidence is presented that a brain fraction containing synaptosomal membrane fragments and ghosts prepared from lysed rat forebrain synaptosomes synthesize protein in a cell free system. The protein synthesis was dependent upon the addition of a synaptosomal membrane fraction, Mg++, monovalent cations, ATP, GTP, and enzyme factors prepared from intact synaptosomes. Protein synthesis was inhibit...
متن کاملEvidence for Protein Synthesis in Synaptosomal Membranes*
Evidence is presented that a brain fraction containing synaptosomal membrane fragments and ghosts prepared from lysed rat forebrain synaptosomes synthesize protein in a cell free system. The protein synthesis was dependent upon the addition of a synaptosomal membrane fraction, Mg++, monovalent cations, ATP, GTP, and enzyme factors prepared from intact synaptosomes. Protein synthesis was inhibit...
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Over the past twenty years, there has been an accumulation of evidence indicating that certain peptides that exert biological effects outside the CNS, may also possess neurotransmitter or neuromodulator functions in brain. Thyroliberin (Thyrotropin-Releasing Hormone) was the first of these such peptides displaying a dual role as a hormone and as a neurotransmitter. Its ubiquitous distribution i...
متن کاملEnhancement by anesthetic and convulsant barbiturates of GABA binding to rat brain synaptosomal membranes.
All of the anesthetic (amylobarbitone, butobarbitone, pentobarbitone, phenobarbitone, and secobarbitone) and convulsant (5-ethyl-5(3'-methylbut-2-enyl) barbituric acid (3M2B) and 5-ethyl-5-(2'-cyclohexylidene-ethyl) barbituric acid (CHEB) barbiturates tested enhanced the binding of GABA to a carefully prepared P2 membrane fraction from rat brain in a dose-dependent manner. These findings are in...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1981
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.78.9.5886